1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Base Information

Chemical Name:1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine
CAS No.:133272-16-9
Molecular Formula:C₂₉H₃₃N₂O₁₀PS
Molecular Weight:632.628
Hs Code.:

Synonyms:1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

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Chemical Property of 1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

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Technology Process of 1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

There total 4 articles about 1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 133272-14-7
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)thymine

: 1005-56-7
phenylcarbonochloridothioate

: 133272-16-9
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: With dmap; In dichloromethane; for 5h; Ambient temperature;

Reference yield:

: 31843-77-3
1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose

: 133272-16-9
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / 1.) hexamethyldisilazane (HDMS), chlorotrimethylsilane (CTS), pyridine, 2.) potassium perfluorobutanesulfonate (KPBS), CTS / 1.) reflux, 2.) MeCN, dichloroethane, reflux, 4 h

2: 63 percent / hydroxylammonium acetate, pyridine / 26 h / Ambient temperature

3: 92 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; dmap; chloro-trimethyl-silane; hydroxylamine acetate; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

Reference yield:

: 65-71-4,80289-22-1
2,4-dihydroxy-5-methylpyrimidine

: 133272-16-9
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / 1.) hexamethyldisilazane (HDMS), chlorotrimethylsilane (CTS), pyridine, 2.) potassium perfluorobutanesulfonate (KPBS), CTS / 1.) reflux, 2.) MeCN, dichloroethane, reflux, 4 h

2: 63 percent / hydroxylammonium acetate, pyridine / 26 h / Ambient temperature

3: 92 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; dmap; chloro-trimethyl-silane; hydroxylamine acetate; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;