7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

Base Information

Chemical Name:7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one
CAS No.:57801-83-9
Molecular Formula:C₁₃H₁₀BrClN₄S
Molecular Weight:369.672
Hs Code.:

Synonyms:7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

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Chemical Property of 7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

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Technology Process of 7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

There total 7 articles about 7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 57801-82-8
7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

: 57801-83-9
7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

Guidance literature:: With hydrazine hydrate; In methanol; for 3.5h; Ambient temperature;
DOI:10.1135/cccc19840621

Reference yield:

: 40017-58-1
2-Amino-3-(o-chlorobenzoyl)-thiophene

: 57801-83-9
7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / CHCl₃ / 1) after mixing slowly heated and refluxed 2 h, 2) standing overnight

2: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

3: 13 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

4: 86 percent / bromine, pyridine / CHCl₃ / 3.75 h / 20 - 24 °C

5: 85 percent / P₂S₅ / pyridine / 2.5 h / 70 - 75 °C

6: 73 percent / hydrazine hydrate / methanol / 3.5 h / Ambient temperature

With pyridine; tetraphosphorus decasulfide; bromine; hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;
DOI:10.1135/cccc19840621

Reference yield:

: 53265-13-7
3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene

: 57801-83-9
7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

2: 13 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

3: 86 percent / bromine, pyridine / CHCl₃ / 3.75 h / 20 - 24 °C

4: 85 percent / P₂S₅ / pyridine / 2.5 h / 70 - 75 °C

5: 73 percent / hydrazine hydrate / methanol / 3.5 h / Ambient temperature

With pyridine; tetraphosphorus decasulfide; bromine; hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;
DOI:10.1135/cccc19840621