Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

Base Information

• Chemical Name: Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester
• CAS No.: 177595-04-9
• Molecular Formula: C₃₅H₄₇NO₁₁
• Molecular Weight: 657.758

Synonyms:Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

Chemical Property of Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

There total 5 articles about Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + Acetic acid (1R,3S,4R,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-formyl-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.03,8]pentadec-11-en-9-yl ester (177595-03-8) → Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.03,8]pentadec-11-en-9-yl ester (177595-04-9)

Guidance literature:

With sodium sulfate; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/0040-4039(96)00495-9

Reference yield:

acetic acid 7,10,13-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-ylester (87193-98-4) → Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.03,8]pentadec-11-en-9-yl ester (177595-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / OsO₄, NMO / acetone; H₂O / 6 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) TEA / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, RT, 30 min

3: 78 percent / Na₂SO₄ / CH₂Cl₂ / 1 h / Ambient temperature

With osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; TEA; dimethyl sulfoxide; sodium sulfate; In dichloromethane; water; acetone;

DOI:10.1016/0040-4039(96)00495-9

Reference yield:

2-desacetoxytaxinine J (119347-14-7) → Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.03,8]pentadec-11-en-9-yl ester (177595-04-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine sulfate / tetrahydrofuran; H₂O; ethanol / 36 h / Heating

2: 94 percent / OsO₄, NMO / acetone; H₂O / 6 h / Ambient temperature

3: 1.) DMSO, oxalyl chloride, 2.) TEA / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, RT, 30 min

4: 78 percent / Na₂SO₄ / CH₂Cl₂ / 1 h / Ambient temperature

With osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; TEA; hydroxylamine sulfate; dimethyl sulfoxide; sodium sulfate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;

DOI:10.1016/0040-4039(96)00495-9

upstream raw materials:

O-benzylhydoxylamine hydrochloride

Acetic acid (1R,3S,4R,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-formyl-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

acetic acid 7,10,13-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-ylester

2-desacetoxytaxinine J

Downstream raw materials:

Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4-hydroxy-5-methanesulfonyloxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 177595-04-9 Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send