2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

Base Information

Chemical Name:2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine
CAS No.:1613475-32-3
Molecular Formula:C₂₃H₂₄ClFN₂O₃
Molecular Weight:430.907
Hs Code.:

Synonyms:2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

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Chemical Property of 2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

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Technology Process of 2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

There total 5 articles about 2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1613475-31-2
N-(5,5-diethoxy-1,1,1-trifluoropent-3-yn-2-ylidene)-4-methoxyaniline

: 104-86-9
4-chlorobenzylamine

: 1613475-32-3
2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

Guidance literature:: With caesium carbonate; In tetrahydrofuran; at 100 ℃; for 8h; Microwave irradiation;

Reference yield: 80.0%

: N-(5,5-diethoxy-1,1,1-trifluoropent-3-yn-2-ylidene)-4-methoxyaniline

: 104-86-9
4-chlorobenzylamine

: 1613475-32-3
2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

Guidance literature:: With caesium carbonate; In tetrahydrofuran; at 100 ℃; for 8h; Microwave irradiation;
DOI:10.1021/acs.orglett.5b01176

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1613475-32-3
2-(4-chlorophenyl)-6-(diethoxymethyl)-3-fluoro-N-(4-methoxyphenyl)pyridin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; tetrachloromethane; triethylamine / tetrachloromethane / 0.17 h / Cooling with ice

1.2: 4 h / Reflux

2.1: copper(l) iodide; potassium phosphate; potassium iodide / acetonitrile / 16 h / 60 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran / 8 h / 100 °C / Microwave irradiation

With tetrachloromethane; potassium phosphate; copper(l) iodide; caesium carbonate; triethylamine; triphenylphosphine; potassium iodide; In tetrahydrofuran; tetrachloromethane; acetonitrile;