(2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol

Base Information

• Chemical Name: (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol
• CAS No.: 1226668-04-7
• Molecular Formula: C₃₃H₃₅N₃O₂
• Molecular Weight: 505.66
• Mol file: 1226668-04-7.mol

Synonyms:(2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol

Chemical Property of (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol

There total 2 articles about (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(4R,5R)-2-Chloro-1,3-dimethyl-4,5-diphenyl-4,5-dihydro-3H-imidazol-1-ium; chloride (198625-67-1,851487-56-4) + (S)-2-amino-3-(4-benzyloxyphenyl)-1-propanol (85803-44-7) → (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol (1226668-04-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/hlca.201300259

Reference yield:

(4R,5R)-1,3-dimethyl-4,5-(diphenyl)-imidazolidin-2-one (360054-69-9) → (2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol (1226668-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride

2: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1002/hlca.201300259

Reference yield: 85.0%

(2S)-3-[4-(benzyloxy)phenyl]-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}propan-1-ol (1226668-04-7) → 4-[(2S)-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}-3-hydroxypropyl]-phenol (1226668-06-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 5h;

DOI:10.1002/hlca.201300259

upstream raw materials:

(4R,5R)-2-Chloro-1,3-dimethyl-4,5-diphenyl-4,5-dihydro-3H-imidazol-1-ium; chloride

(S)-2-amino-3-(4-benzyloxyphenyl)-1-propanol

(4R,5R)-1,3-dimethyl-4,5-(diphenyl)-imidazolidin-2-one

Downstream raw materials:

4-[(2S)-2-{[(4R,5R)-1,3-dimethyl-4,5-diphenylimidazolidin-2-ylidene]amino}-3-hydroxypropyl]-phenol