(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine

Base Information

• Chemical Name: (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine
• CAS No.: 182075-03-2
• Molecular Formula: C₂₀H₂₂F₂N₄O₄S₂
• Molecular Weight: 484.548
• Mol file: 182075-03-2.mol

Synonyms:(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine

Chemical Property of (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine

There total 3 articles about (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfilimine (181885-57-4,220433-96-5) → (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine (182075-03-2)

Guidance literature:

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

Reference yield:

chloroamine-T (127-65-1) → (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine (182075-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / methanol / Ambient temperature

2: 88 percent / MCPBA, K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylthio)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (133775-27-6) → (R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfoximine (182075-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / methanol / Ambient temperature

2: 88 percent / MCPBA, K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

(S)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methyl-N-tosylsulfilimine

chloroamine-T

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylthio)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Downstream raw materials:

(R)-S-2-<(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)>butyl-S-methylsulfoximine