5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester
• CAS No.: 1579277-92-1
• Molecular Formula: C₂₁H₂₆FN₇O₄
• Molecular Weight: 459.48
• Mol file: 1579277-92-1.mol

Synonyms:5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester

Chemical Property of 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester

There total 3 articles about 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 0.72%

1-Fluoro-2-isocyanato-benzene (16744-98-2) + 1-(2-piperidin-1-yl-ethyl)-1H-imidazole-4,5-dicarboxylic acid dimethyl ester (1579277-80-7) + guanidine hydrochloride (50-01-1) → 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester (1579277-92-1)

Guidance literature:

guanidine hydrochloride; With sodium methylate; In methanol; at 0 ℃; for 0.5h;

1-(2-piperidin-1-yl-ethyl)-1H-imidazole-4,5-dicarboxylic acid dimethyl ester; In methanol; at 20 ℃; for 8h;

1-Fluoro-2-isocyanato-benzene; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.3390/molecules181113385

Reference yield:

dimethyl imidazole-4,5-dicarboxylate (3304-70-9) → 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester (1579277-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 48 h / 20 °C

2.1: sodium methylate / methanol / 0.5 h / 0 °C

2.2: 8 h / 20 °C

2.3: 24 h / 20 °C

With sodium methylate; potassium carbonate; In methanol; acetonitrile;

DOI:10.3390/molecules181113385

Reference yield:

N-chloroethylpiperidine hydrochloride (2008-75-5) → 5-({[3-(2-fluorophenyl)ureido]iminomethyl}carbamoyl)-3-(2-piperidin-1-yl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester (1579277-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 48 h / 20 °C

2.1: sodium methylate / methanol / 0.5 h / 0 °C

2.2: 8 h / 20 °C

2.3: 24 h / 20 °C

With sodium methylate; potassium carbonate; In methanol; acetonitrile;

DOI:10.3390/molecules181113385

upstream raw materials:

N-chloroethylpiperidine hydrochloride

dimethyl imidazole-4,5-dicarboxylate

1-Fluoro-2-isocyanato-benzene

1-(2-piperidin-1-yl-ethyl)-1H-imidazole-4,5-dicarboxylic acid dimethyl ester