dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

Base Information

Chemical Name:dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate
CAS No.:118252-52-1
Molecular Formula:C₂₅H₃₂N₆O₈
Molecular Weight:544.564
Hs Code.:

Synonyms:dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

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Chemical Property of dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

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Technology Process of dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

There total 6 articles about dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52407-60-0
dimethyl N-(4-amino-benzoyl)-L-glutamate

: 118252-51-0
2-acetamido-8-acetyl-5,6,7,8-tetrahydro-7-hydroxypyrido<2,3-d>pyrimidin-4(3H)-one

: 144-55-8
sodium hydrogencarbonate

: 118252-52-1
dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

Guidance literature:: With sodium cyanoborohydride; acetic acid; silica gel; In methanol; chloroform; ethyl acetate;

Reference yield:

: 118252-49-6
3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde diethyl acetal

: 118252-52-1
dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / 1.) 90 deg C, 6 h, 2.) room temp., overnight

2: 76 percent / H₂O / 4 h / 100 °C

3: AcOH, 3A sieves / methanol / 3 h

4: NaBH₃CN, AcOH / methanol / 16 h

With pyridine; 3 A molecular sieve; water; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/jm00164a014

Reference yield:

: 118252-50-9
3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propionaldehyde diethyl acetal

: 118252-52-1
dimethyl N-<4-<<3-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂O / 4 h / 100 °C

2: AcOH, 3A sieves / methanol / 3 h

3: NaBH₃CN, AcOH / methanol / 16 h

With 3 A molecular sieve; water; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/jm00164a014