trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-83-2
Molecular Formula:C₃₄H₃₈FN₃O₃
Molecular Weight:555.692
Hs Code.:

Synonyms:trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Chemical Property of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Technology Process of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 4 articles about trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357001-60-5
AMN-2trans

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 1357001-83-2
trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: AMN-2trans; 3,4-dimethoxyphenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 120 ℃; for 0.333333h; Microwave irradiation;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h;

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1357001-83-2
trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 2 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 120 °C / Microwave irradiation

2.2: 2 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

Reference yield:

: 863514-54-9
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

: 1357001-83-2
trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 16 h / Inert atmosphere

1.2: 2 h / 20 °C

1.3: 1 h / cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 120 °C / Microwave irradiation

2.2: 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;