AMN-2trans

Base Information

• Chemical Name: AMN-2trans
• CAS No.: 1357001-60-5
• Molecular Formula: C₂₄H₂₈FN₃
• Molecular Weight: 377.505

Synonyms:AMN-2trans

Chemical Property of AMN-2trans

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Technology Process of AMN-2trans

There total 2 articles about AMN-2trans which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one (863514-54-9) + tryptamine (61-54-1) → AMN-2trans (1357001-60-5) + AMN-2cis (1357001-59-2)

Guidance literature:

4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one; tryptamine; In methanol; for 16h; Inert atmosphere;

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

With sodium hydroxide; In water; 1,2-dichloro-ethane; for 1h; cooling with ice;

Reference yield:

[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride (1002916-54-2) → AMN-2trans (1357001-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: methanol / 16 h / Inert atmosphere

2.2: 2 h / 20 °C

2.3: 1 h / cooling with ice

With hydrogenchloride; water; In methanol;

Reference yield: 12.0%

benzothiophene-2-carboxylic acid chloride (39827-11-7) + AMN-2trans (1357001-60-5) → AMD-3trans (1357001-79-6)

Guidance literature:

benzothiophene-2-carboxylic acid chloride; AMN-2trans; In tetrahydrofuran; at 20 ℃; for 3.25h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; water; for 2.5h; cooling with ice;

upstream raw materials:

4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

tryptamine

[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride

Downstream raw materials:

trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)

AMD-3trans

trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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