{(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol

Base Information

• Chemical Name: {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol
• CAS No.: 1222456-90-7
• Molecular Formula: C₁₇H₂₂N₄O₂
• Molecular Weight: 314.387
• Mol file: 1222456-90-7.mol

Synonyms:{(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol

Chemical Property of {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol

There total 2 articles about {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((3R,6R)-6-methylpiperidin-3-yl)-methanol (1088993-98-9) + 5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride (1104546-96-4) → {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol (1222456-90-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid (956317-36-5) + ((3R,6R)-6-methylpiperidin-3-yl)-methanol (1088993-98-9) → {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol (1222456-90-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.02.026

Reference yield:

{(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol (1222456-90-7) + methanesulfonyl chloride (124-63-0) → {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methyl methanesulfonate (1222456-92-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

((3R,6R)-6-methylpiperidin-3-yl)-methanol

5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

Downstream raw materials:

{(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methyl methanesulfonate

(2R,5R)-5-[(3-fluorophenoxy)methyl]-2-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidine