Technology Process of (1R,2R)-1,2-diphenylpentan-1-ol
There total 2 articles about (1R,2R)-1,2-diphenylpentan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
RuCl2[(S)-xyl-SEGPHOS][(S)-DAIPEN]; potassium tert-butylate; hydrogen;
In
isopropyl alcohol;
at 25 ℃;
for 16h;
under 5171.62 Torr;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ol800858c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C
1.2: 2 h / 3 - 20 °C
2.1: RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; hydrogen; potassium tert-butylate / isopropyl alcohol / 40 h / 25 °C / 5171.62 Torr / Glovebox
With
RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; potassium tert-butylate; hydrogen;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jo3023928
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
2.1: benzene / Irradiation
3.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C
3.2: 2 h / 3 - 20 °C
4.1: RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; hydrogen; potassium tert-butylate / isopropyl alcohol / 40 h / 25 °C / 5171.62 Torr / Glovebox
5.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
6.1: dimethylsulfoxide-d6 / 0.5 h
7.1: aq. buffer / 0.25 h / Inert atmosphere; Irradiation
With
RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; potassium tert-butylate; hydrogen; Dess-Martin periodane;
In
tetrahydrofuran; dimethylsulfoxide-d6; dichloromethane; isopropyl alcohol; benzene;
1.1: |Dess-Martin Oxidation / 5.1: |Dess-Martin Oxidation;
DOI:10.1021/jo3023928