(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Base Information

Chemical Name:(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate
CAS No.:322468-29-1
Molecular Formula:C₂₆H₃₆BrO₇P
Molecular Weight:571.445
Hs Code.:

Synonyms:(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Suppliers and Price of (3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

There total 9 articles about (3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 15687-27-1,58560-75-1
ibuprofen

: 322468-25-7
((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

: 322468-29-1
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 2h;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 17618-04-1
2,5-di-O-benzyl-D-mannitol

: 322468-29-1
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

3: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

4: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

5: tetrahydrofuran / 2 h / -78 - 20 °C

6: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

7: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

8: 91 percent / DCC; DMAP / CH₂Cl₂ / 2 h

With dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 114978-02-8
2,5-di-O-benzyl-1,3(R):4,6(R)-di-O-benzylidene-D-mannitol

: 322468-29-1
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / aq. HCl / ethanol / 4 h / Heating

2: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

3: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

4: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

5: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

6: tetrahydrofuran / 2 h / -78 - 20 °C

7: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

8: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

9: 91 percent / DCC; DMAP / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5