2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

Base Information

Chemical Name:2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine
CAS No.:1427588-43-9
Molecular Formula:C₂₀H₂₅N₅O₂
Molecular Weight:367.451
Hs Code.:

Synonyms:2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

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Chemical Property of 2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

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Technology Process of 2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

There total 8 articles about 2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1427588-89-3
{4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl methanesulfonate

: 1427588-43-9
2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

Guidance literature:: 2-(N-tert-butoxycarbonylamino)ethanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 0.5h;

{4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl methanesulfonate; In N,N-dimethyl-formamide; at 65 - 80 ℃; for 22h;

Reference yield:

: 1427555-72-3
{4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl acetate

: 1427588-43-9
2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; acetic acid / water / 0.08 h

2.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation

3.1: potassium carbonate; methanol / 0.5 h

4.1: triethylamine / dichloromethane / 1 h

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

5.2: 22 h / 65 - 80 °C

With methanol; potassium phosphate; copper(l) iodide; sodium hydride; potassium carbonate; acetic acid; triethylamine; N,N`-dimethylethylenediamine; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1427588-82-6
tert-butyl 2-[(acetyloxy)methyl]morpholine-4-carboxylate

: 1427588-43-9
2-({4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methoxy)ethan-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane

2.1: triethylamine / methanol; 1,2-dichloro-ethane / 0.5 h / 0 °C

2.2: 78 h / 60 °C

3.1: sodium nitrite; acetic acid / water / 0.08 h

4.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation

5.1: potassium carbonate; methanol / 0.5 h

6.1: triethylamine / dichloromethane / 1 h

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

7.2: 22 h / 65 - 80 °C

With methanol; potassium phosphate; copper(l) iodide; sodium hydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; N,N`-dimethylethylenediamine; sodium nitrite; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;