2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

Base Information

Chemical Name:2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole
CAS No.:219586-46-6
Molecular Formula:C₂₀H₃₂N₂O₃S
Molecular Weight:380.552
Hs Code.:

Synonyms:2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

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Chemical Property of 2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

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Technology Process of 2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

There total 1 articles about 2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 116-11-0
2-Methoxypropene

: ((S)-1-Cyclohexylmethyl-2-hydroxy-2-thiazol-2-yl-ethyl)-carbamic acid tert-butyl ester

: 143131-18-4
2-<(4S,5R)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: 219586-46-6
2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

Guidance literature:: With pyridinium p-toluenesulfonate; In toluene; at 100 ℃; for 18h; Heating;
DOI:10.1021/jo980980u

Reference yield:

: 219586-46-6
2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: (2R,3s,4S)-2,4-diamino-1,5-dicyclohexyl-3-pentanol

Guidance literature:: Multi-step reaction with 5 steps

2: MgSO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

3: Et₂AlCl / diethyl ether; tetrahydrofuran; hexane / 3 h / -78 °C

4: H₂ / Pd(OH)2 / acetic acid; ethanol / 18 h / 2280 Torr / Ambient temperature

5: HCl / H₂O / 3 h / 90 °C

With hydrogenchloride; hydrogen; diethylaluminium chloride; magnesium sulfate; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; acetic acid;
DOI:10.1021/jo980980u

Reference yield:

: 219586-46-6
2-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: (4S,5R)-5-((R)-1-Amino-2-cyclohexyl-ethyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: MgSO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

3: Et₂AlCl / diethyl ether; tetrahydrofuran; hexane / 3 h / -78 °C

4: H₂ / Pd(OH)2 / acetic acid; ethanol / 18 h / 2280 Torr / Ambient temperature

With hydrogen; diethylaluminium chloride; magnesium sulfate; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jo980980u