Technology Process of (R)-2-((S)-2-methoxy-1-phenylethylamino)-1,1,2-triphenylethanol
There total 3 articles about (R)-2-((S)-2-methoxy-1-phenylethylamino)-1,1,2-triphenylethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-(-)-benzylidene(2-methoxy-1-phenylethyl)amine;
With
titanium(IV) isopropylate; cyclopentylmagnesium chloride;
In
diethyl ether;
at -30 ℃;
for 3h;
Inert atmosphere;
benzophenone;
In
diethyl ether;
at -30 - 20 ℃;
for 2h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
diethyl ether; water;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2012.07.020
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere; Reflux
2.1: magnesium sulfate / dichloromethane / Inert atmosphere
3.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride / diethyl ether / 3 h / -30 °C / Inert atmosphere
3.2: 2 h / -30 - 20 °C / Inert atmosphere
3.3: 1 h / 20 °C / Inert atmosphere
With
titanium(IV) isopropylate; sodium hydride; cyclopentylmagnesium chloride; magnesium sulfate;
In
tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2012.07.020
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium sulfate / dichloromethane / Inert atmosphere
2.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride / diethyl ether / 3 h / -30 °C / Inert atmosphere
2.2: 2 h / -30 - 20 °C / Inert atmosphere
2.3: 1 h / 20 °C / Inert atmosphere
With
titanium(IV) isopropylate; cyclopentylmagnesium chloride; magnesium sulfate;
In
diethyl ether; dichloromethane;
DOI:10.1016/j.tetlet.2012.07.020