(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

Base Information

Chemical Name:(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester
CAS No.:1036759-16-6
Molecular Formula:C₃₁H₃₉N₃O₅
Molecular Weight:533.668
Hs Code.:

Synonyms:(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

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Chemical Property of (2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

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Technology Process of (2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

There total 4 articles about (2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 371226-28-7
O-(9-azabicyclo[3.3.1]nonan-3α-yl)-N-(2-methoxy-5-methylphenyl)carbamate

: 24566-79-8
2-(6-bromohexyl)isoindole-1,3-dione

: 1036759-16-6
(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; Reflux;

Reference yield:

: 59741-04-7
2-methoxy-5-methylphenyl isocyanate

: 1036759-16-6
(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dibutyltin diacetate / dichloromethane / 20 °C

2: palladium hydroxide, 20 wt% on carbon; ammonium formate / methanol; ethyl acetate / 6 h / Reflux

3: potassium iodide; potassium carbonate / acetonitrile / Reflux

With palladium hydroxide, 20 wt% on carbon; ammonium formate; dibutyltin diacetate; potassium carbonate; potassium iodide; In methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 70243-51-5
3-endo-hydroxy-9-benzyl-9-azabicyclo[3.3.1]nonane

: 1036759-16-6
(2-Methoxy-5-methyl-phenyl)-carbamic acid (1R,3R,5S)-9-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexyl]-9-aza-bicyclo[3.3.1]non-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dibutyltin diacetate / dichloromethane / 20 °C

2: palladium hydroxide, 20 wt% on carbon; ammonium formate / methanol; ethyl acetate / 6 h / Reflux

3: potassium iodide; potassium carbonate / acetonitrile / Reflux

With palladium hydroxide, 20 wt% on carbon; ammonium formate; dibutyltin diacetate; potassium carbonate; potassium iodide; In methanol; dichloromethane; ethyl acetate; acetonitrile;