(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

Base Information

Chemical Name:(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone
CAS No.:186808-30-0
Molecular Formula:C₁₆H₁₇N₃O₃
Molecular Weight:299.329
Hs Code.:

Synonyms:(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

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Chemical Property of (1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

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Technology Process of (1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

There total 5 articles about (1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-b]azepine

: 122-04-3
4-nitro-benzoyl chloride

: 186808-30-0
(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Yield given; Ambient temperature;
DOI:10.3987/COM-98-8104

Reference yield:

: 13754-86-4
1,5,6,7-tetrahydro-indol-4-one

: 186808-30-0
(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylammonium chloride, pyridine / 2 h / Ambient temperature

2: diisobutylaluminum hydride / CH₂Cl₂ / 3 h / 0 °C

3: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

4: NaH / tetrahydrofuran; dimethylformamide

With pyridine; hydroxylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-98-8104

Reference yield:

: 27866-27-9
1,5,6,7-tetrahydro-indol-4-one oxime

: 186808-30-0
(1-Methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-(4-nitro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminum hydride / CH₂Cl₂ / 3 h / 0 °C

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: NaH / tetrahydrofuran; dimethylformamide

With sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-98-8104