8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

Base Information

Chemical Name:8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole
CAS No.:183612-80-8
Molecular Formula:C₂₃H₂₅NO
Molecular Weight:331.458
Hs Code.:

Synonyms:8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

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Chemical Property of 8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

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Technology Process of 8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

There total 13 articles about 8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 183612-79-5
(6aS,9aS)-8-Benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-benzo[4,5]indeno[1,7a-c]pyrrol-6-one

: 183612-80-8
8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; diethyl ether; for 6h; Ambient temperature;
DOI:10.1021/ja961903o

Reference yield:

: 5020-41-7
2-(3-methoxyphenyl)-ethanol

: 183612-80-8
8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

Guidance literature:: Multi-step reaction with 10 steps

1: 96.7 percent / PPh₃, I₂, imidazole / CH₂Cl₂ / 3 h / Ambient temperature

2: 95 percent / Br₂ / CH₂Cl₂ / 2 h / -10 °C

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, 0 deg C, 6 h

4: KH / tetrahydrofuran / 1.5 h / 25 °C

5: 30percent aq. H₂O₂ / 12 h / Ambient temperature

6: 84 percent / trifluoroacetic acid / benzene; CH₂Cl₂ / 36 h

7: 1.) KH, 2.) t-BuLi / 1.) THF, -78 deg C, 40 min, 2.) THF, pentane, -78 deg C, 15 min

8: 1 M aq. (n-Bu)4NH₂PO₄ / CH₂Cl₂ / 13 h / 40 °C

9: NaH / ethanol; benzene / 20 h / Ambient temperature

10: 95.2 percent / LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; aluminium trichloride; dihydrogen peroxide; bromine; iodine; tert.-butyl lithium; potassium hydride; sodium hydride; tetrabutylammonium dihydrogen phosphate; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/ja961903o

Reference yield:

: 25226-97-5
3-methoxyphenethyl iodide

: 183612-80-8
8-benzyl-2-methoxy-6a,7,8,9,10,11-hexahydro-6H-benzo[4,5]indeno[1,7a-c]pyrrole

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / Br₂ / CH₂Cl₂ / 2 h / -10 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, 0 deg C, 6 h

3: KH / tetrahydrofuran / 1.5 h / 25 °C

4: 30percent aq. H₂O₂ / 12 h / Ambient temperature

5: 84 percent / trifluoroacetic acid / benzene; CH₂Cl₂ / 36 h

6: 1.) KH, 2.) t-BuLi / 1.) THF, -78 deg C, 40 min, 2.) THF, pentane, -78 deg C, 15 min

7: 1 M aq. (n-Bu)4NH₂PO₄ / CH₂Cl₂ / 13 h / 40 °C

8: NaH / ethanol; benzene / 20 h / Ambient temperature

9: 95.2 percent / LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

With lithium aluminium tetrahydride; aluminium trichloride; dihydrogen peroxide; bromine; tert.-butyl lithium; potassium hydride; sodium hydride; tetrabutylammonium dihydrogen phosphate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/ja961903o