N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide

Base Information

• Chemical Name: N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide
• CAS No.: 114692-04-5
• Molecular Formula: C₂₁H₂₃NO₂
• Molecular Weight: 321.419
• Mol file: 114692-04-5.mol

Synonyms:N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide

Chemical Property of N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide

There total 3 articles about N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-4'-acetylbiphenyl (5731-01-1) → N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide (114692-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / benzene

2: 1.) Mg / 1.) THF, reflux, 12 h; 2.) room temp.

3: 1.) triethylamine, ethyl chloroformate / 1.) DMF, 30 min; 2.) H₂O, acetone, 20 min

With chloroformic acid ethyl ester; magnesium; triethylamine; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/ja00221a032

Reference yield:

anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane (107967-74-8) → N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide (114692-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) THF, reflux, 12 h; 2.) room temp.

2: 1.) triethylamine, ethyl chloroformate / 1.) DMF, 30 min; 2.) H₂O, acetone, 20 min

With chloroformic acid ethyl ester; magnesium; triethylamine;

DOI:10.1021/ja00221a032

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) + 4-acetyl-4'-biphenylcarboxylic acid (114691-92-8) → N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide (114692-04-5)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; Multistep reaction; 1.) DMF, 30 min; 2.) H₂O, acetone, 20 min;

DOI:10.1021/ja00221a032

upstream raw materials:

cyclohexylamine

4-acetyl-4'-biphenylcarboxylic acid

4-bromo-4'-acetylbiphenyl

anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane