3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Base Information

Chemical Name:3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
CAS No.:97277-72-0
Molecular Formula:C₂₂H₂₆N₂O₃S
Molecular Weight:398.526
Hs Code.:

3(R)-<N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Synonyms:3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

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Chemical Property of 3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

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Technology Process of 3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

There total 9 articles about 3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 97277-72-0
3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / aq. NaOH / Ambient temperature

2: 82 percent / NH₄Cl, Zn / methanol / 1.) reflux, 4 h, 2.) RT, overnight

3: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 3 h

4: 68 percent / 31percent HBr in HOAc / 1 h / Ambient temperature

5: 25.4 g / BF₃*Et₂O / CHCl₃ / 18 h / Ambient temperature

6: sodium cyanoborohydride, glacial acetic acid / ethanol

With sodium hydroxide; boron trifluoride diethyl etherate; hydrogen bromide; sodium cyanoborohydride; ammonium chloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a024

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 97277-72-0
3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 25.4 g / BF₃*Et₂O / CHCl₃ / 18 h / Ambient temperature

2: sodium cyanoborohydride, glacial acetic acid / ethanol

With boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; In ethanol; chloroform;
DOI:10.1021/jm00148a024

Reference yield:

: 91088-54-9
N-acetyl-S-(2-nitro-phenyl)-L-cysteine

: 97277-72-0
3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / 18 M aq. H₂SO₄ / H₂O / 0.5 h / Heating

2: 81 percent / aq. NaOH / Ambient temperature

3: 82 percent / NH₄Cl, Zn / methanol / 1.) reflux, 4 h, 2.) RT, overnight

4: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 3 h

5: 68 percent / 31percent HBr in HOAc / 1 h / Ambient temperature

6: 25.4 g / BF₃*Et₂O / CHCl₃ / 18 h / Ambient temperature

7: sodium cyanoborohydride, glacial acetic acid / ethanol

With sodium hydroxide; sulfuric acid; boron trifluoride diethyl etherate; hydrogen bromide; sodium cyanoborohydride; ammonium chloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a024