1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

Base Information

Chemical Name:1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone
CAS No.:896745-79-2
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

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Chemical Property of 1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

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Technology Process of 1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

There total 4 articles about 1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 896745-78-1
1-(2-benzyloxy-4-methylphenyl)-2-hydroxy-ethanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 896745-79-2
1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/ol060382z

Reference yield:

: 6921-64-8
4'-hydroxy-2'-methylacetophenone

: 896745-79-2
1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / potassium iodide; potassium carbonate / acetonitrile / 70 °C

2.1: LDA; trimethylsilyl chloride / tetrahydrofuran / 2.5 h / -78 - 20 °C

2.2: anhydrous NaHCO₃; m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 20 °C

2.3: 65 percent / aq. HCl / CH₂Cl₂ / 3 h / 20 °C

3.1: 100 percent / imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol060382z

Reference yield:

: 100-44-7
benzyl chloride

: 896745-79-2
1-(2-benzyloxy-4-methylphenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / potassium iodide; potassium carbonate / acetonitrile / 70 °C

2.1: LDA; trimethylsilyl chloride / tetrahydrofuran / 2.5 h / -78 - 20 °C

2.2: anhydrous NaHCO₃; m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 20 °C

2.3: 65 percent / aq. HCl / CH₂Cl₂ / 3 h / 20 °C

3.1: 100 percent / imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol060382z