3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

Base Information

Chemical Name:3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide
CAS No.:1380106-83-1
Molecular Formula:C₁₈H₂₄ClNO₄
Molecular Weight:353.846
Hs Code.:

Synonyms:3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

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Chemical Property of 3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

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Technology Process of 3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

There total 4 articles about 3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1380106-84-2
C₁₃H₁₅ClO₃

: 1380106-83-1
3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.04.019

Reference yield:

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1380106-83-1
3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

2: tetrahydrofuran / 2 h / Reflux

3: sodium hydrogencarbonate / methanol / 1 h / 20 °C

4: caesium carbonate / acetonitrile / 24 h / 20 °C

5: water; sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

With water; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.019

Reference yield:

: 1380106-82-0
3-(2-chloro-4-hydroxy-phenyl)-acrylic acid methyl ester

: 1380106-83-1
3-(2-chloro-4-isobutoxy-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 24 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.019