1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide

Base Information

• Chemical Name: 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide
• CAS No.: 1322724-54-8
• Molecular Formula: C₁₉H₂₅N₅OS
• Molecular Weight: 371.506

Synonyms:1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide

Chemical Property of 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide

Chemical Property:

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Technology Process of 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide

There total 2 articles about 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C12H14N4O (184898-81-5) + isothiocyanatocyclohexane (1122-82-3) → 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide (1322724-54-8)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1007/s00044-011-9691-4

Reference yield:

ethyl [(3-methyl-5-phenyl)-1H-pyrazol-1-yl]acetate (184898-80-4) → 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide (1322724-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / Reflux

2: ethanol / 6 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9691-4

Reference yield: 70.0%

1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide (1322724-54-8) + 4-chlorobenzoylmethyl bromide (536-38-9) → N'-(4-(4-chlorophenyl)-3-cyclohexylthiazol-2(3H)-ylidene)-2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetohydrazide

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux;

DOI:10.1016/j.bioorg.2021.104883

upstream raw materials:

ethyl [(3-methyl-5-phenyl)-1H-pyrazol-1-yl]acetate

C₁₂H₁₄N₄O

isothiocyanatocyclohexane

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