3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

Base Information

Chemical Name:3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine
CAS No.:79707-54-3
Molecular Formula:C₁₈H₂₅N₃O
Molecular Weight:299.416
Hs Code.:

Synonyms:3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

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Chemical Property of 3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

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Technology Process of 3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

There total 4 articles about 3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 506-59-2
N,N-dimethylammonium chloride

: 79707-51-0
2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

: 79707-54-3
3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

Guidance literature:: In ethanol; for 4h; Heating;
DOI:10.1021/jm00394a018

Reference yield:

: 79707-53-2
2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridine

: 79707-54-3
3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 6 N aq. hydrochloric acid, H₂ / 10percent Pd/C / ethanol / 70 h / 2844.3 Torr / Ambient temperature

2: 1.) sodium hydride / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, 85-90 deg C, 1.5 h

3: 78 percent / ethanol / 4 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00394a018

Reference yield:

: 100-44-7
benzyl chloride

: 79707-54-3
3-<(dimethylamino)methyl>-2-methyl-8-(phenylmethoxy)-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, 85-90 deg C, 1.5 h

2: 78 percent / ethanol / 4 h / Heating

With sodium hydride; In ethanol;
DOI:10.1021/jm00394a018