2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Base Information

Chemical Name:2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester
CAS No.:1268375-33-2
Molecular Formula:C₁₂H₁₀Cl₂O₄S₂
Molecular Weight:353.247
Hs Code.:

Synonyms:2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Suppliers and Price of 2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 8 raw suppliers

Chemical Property of 2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Chemical Property:

Melting Point:141.6-142.9 °C
Boiling Point:457.2±40.0 °C(Predicted)
Density:1.501±0.06 g/cm3(Predicted)

Purity/Quality:: 99.0% ^*data from raw suppliers

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MSDS Files:

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Technology Process of 2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

There total 4 articles about 2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 39076-88-5
2,5-dichlorothieno[3,2-b]thiophene

: 541-41-3
chloroformic acid ethyl ester

: 1268375-33-2
2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Guidance literature:: With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 5 - 23 ℃; for 43h;

Reference yield: 81.0%

: 1268375-16-1
ethyl 2,5-dichlorothieno[3,2-b]thiophene-3-carboxylate

: 623-49-4
ethyl cyanoformate

: 1268375-33-2
2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Guidance literature:: ethyl 2,5-dichlorothieno[3,2-b]thiophene-3-carboxylate; With 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; In tetrahydrofuran; at -20 ℃; Inert atmosphere;

ethyl cyanoformate; In tetrahydrofuran; at -20 - 20 ℃; for 12h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201002506

Reference yield:

: 251-41-2
thieno[3,2-b]thiophene

: 1268375-33-2
2,5-dichloro-thieno[3,2-b]thiophene-3,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

2.2: 1 h / -40 - 20 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

3.2: 12 h / -20 - 20 °C / Inert atmosphere

With N-chloro-succinimide; 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002506