2-(4-Aminophenoxy)naphthalene

Base Information

• Chemical Name: 2-(4-Aminophenoxy)naphthalene
• CAS No.: 71311-83-6
• Molecular Formula: C16H13 N O
• Molecular Weight: 235.285
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID50393853
• Nikkaji Number: J32.586D
• Mol file: 71311-83-6.mol

Synonyms:71311-83-6;2-(4-Aminophenoxy)naphthalene;4-(naphthalen-2-yloxy)aniline;4-naphthalen-2-yloxyaniline;4-(2-naphthyloxy)aniline;Benzenamine, 4-(2-naphthalenyloxy)-;p-(2-Naphthyloxy)aniline;Oprea1_218318;SCHEMBL1177704;DTXSID50393853;FLSZEMCAUKGBBK-UHFFFAOYSA-N;4-(2-Naphthalenyloxy)-benzenamine;4-(Naphthalen-2-yloxy)phenylamine;MFCD00443717;STK389242;(4-naphthalen-2-yloxy-phenyl)-amine;AKOS000215502;SB80652;AM20041066;CS-0315640;T71259

Chemical Property of 2-(4-Aminophenoxy)naphthalene

Chemical Property:

• Vapor Pressure: 2.95E-07mmHg at 25°C
• Melting Point: 116 °C
• Refractive Index: 1.686
• Boiling Point: 419.8°C at 760 mmHg
• Flash Point: 221.8°C
• PSA: 35.25000
• Density: 1.197g/cm³
• LogP: 4.79550
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 260

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Naphthalenyloxy)benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)OC3=CC=C(C=C3)N
• Uses: 4-(2-Naphthalenyloxy)benzenamine is used as a reactant in organic synthesis.

Technology Process of 2-(4-Aminophenoxy)naphthalene

There total 7 articles about 2-(4-Aminophenoxy)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-nitrophenyl 2-naphthyl ether (71311-82-5) → 4-(naphthalen-2-yloxy)phenylamine (71311-83-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrazine hydrate; In ethanol; for 18h; Inert atmosphere; Reflux;

DOI:10.1155/2015/465286

Reference yield:

para-nitrophenyl bromide (586-78-7) → 4-(naphthalen-2-yloxy)phenylamine (71311-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0.3 h, 2.) DMF, RT, overnight

2: H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm9605041

Reference yield:

β-naphthol (135-19-3) → 4-(naphthalen-2-yloxy)phenylamine (71311-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0.3 h, 2.) DMF, RT, overnight

2: H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm9605041

upstream raw materials:

4-nitrophenyl 2-naphthyl ether

para-nitrophenyl bromide

β-naphthol

4-Fluoronitrobenzene

Downstream raw materials:

N'-[4-(2-naphthyloxy)phenyl]-N,N-dimethylurea

4-(2-naphthyloxy)phenyl isocyanate

3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)phenyl)benzamide

N-(4-(N-(4-(naphthalen-2-yloxy)phenyl)sulfamoyl)phenyl)acetamide