4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

Base Information

Chemical Name:4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester
CAS No.:1586791-50-5
Molecular Formula:C₁₈H₂₄N₄O₃
Molecular Weight:344.414
Hs Code.:

Synonyms:4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

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Chemical Property of 4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

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Technology Process of 4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

There total 4 articles about 4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 16034-48-3
pyrazol-1-yl-acetic acid

: 1291986-72-5
methyl 3-amino-4-(1-ethyl-propylamino)-benzoate

: 1586791-50-5
4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1586791-50-5
4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 3 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 3750.38 Torr

4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1586791-50-5
4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 3750.38 Torr

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;