16034-48-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(1H-Pyrazol-1-yl)acetic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical structure and reactivity.
Used in Anti-Inflammatory and Analgesic Applications:
In the medical field, 2-(1H-Pyrazol-1-yl)acetic acid is used as an anti-inflammatory and analgesic agent, helping to reduce inflammation and alleviate pain.
Used in Brain Disorder Treatment:
2-(1H-Pyrazol-1-yl)acetic acid is being investigated for its potential use in the treatment of brain disorders, such as neurodegenerative diseases, due to its ability to modulate certain biological pathways involved in these conditions.
Used in Cancer Therapy:
In the oncology field, 2-(1H-Pyrazol-1-yl)acetic acid is used as an enzyme inhibitor, targeting enzymes that play a role in cancer cell proliferation and growth, thereby showing potential as a therapeutic agent in cancer treatment.
Overall, 2-(1H-Pyrazol-1-yl)acetic acid demonstrates its potential as a versatile chemical with applications in various industries, particularly in the pharmaceutical and medical fields, due to its diverse pharmacological properties and its role in the synthesis of therapeutic compounds.

InChI:InChI=1/C5H6N2O2/c8-5(9)4-7-3-1-2-6-7/h1-3H,4H2,(H,8,9)

Upstream product

• 10199-61-8 pyrazol-1-yl acetic acid ethyl ester 
• 288-13-1 NH-pyrazole 
• 79-08-3 bromoacetic acid 
• 26214-05-1 octyltrimethylammonium hydroxide 
• 96-34-4 methyl chloroacetate 
• 79-11-8 chloroacetic acid 
• 934175-49-2 2-(1H-pyrazol-1-yl)acetohydrazide 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1586791-50-5 4-(1-ethyl-propylamino)-3-(2-pyrazol-1-yl-acetylamino)-benzoic acid methyl ester 
• 1558058-13-1 C₂₇H₃₃N₅O₄ 
• 1245631-33-7 C₂₆H₂₉N₇O₂ 
• 1010816-01-9 C₂₂H₂₃FN₆O₄ 
• 863971-99-7 {(S)-3-phenyl-2-[(2-pyrazol-1-yl)acetylamino]propionylamino}acetic acid 

Relevant academic research and scientific papers

Versatile polyiodopyrazoles: Synthesis and biocidal promise

An efficient route to polyiodopyrazoles, 3,4,5-triiodopyrazole (1), 1-methyl-3,4,5-triiodopyrazole (2) and 1-diiodomethyl-3,4,5-triiodopyrazole (3), opens the door to prospective biocides. Nitration of 1 and 2 gives the previously inaccessible compounds,

Spectroscopic, thermal and antimicrobial study of some transition metal(II) complexes of β-diketones

A novel heterocyclic based β-diketone has been synthesized by the condensation of pyrazole-1-acetylchloride and sodium acetophenone. The product 1-phenyl-4-(pyrazole-1-yl)butane-1,3-dione has been used for complexation with Mn(II), Fe(II) and Co(II) metal ions. The ligand β-diketone is found to exist in keto-enol tautomeric forms. The comparision of infrared spectra of complexes clearly indicates the coordination of the ligand from its enolic form. The magnetic moment and electronic spectra of all the metal complexes leads to the distorted octahedral symmetry around the metal ion. The ligand as well as its metal complexes has been screened for antimicrobial activity and antifungal activities. It is observed that the antimicrobial and antifungal activities get enhanced in complexes in respect to the free ligand.

Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and C-pyrazolyl-substituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine- 3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.

Addition of (pyrazol-1-yl)acetyl and (pyridin-2-yl)acetyl groups to the terminal amino group of a Phe-Gly dipeptide affords ATCUN-like copper(II) binding sites

(Pyrazol-1-yl)acetic acid (HL1, 1) and (pyridin-2-yl)acetic acid have been successfully condensed with the terminal amino group of a Phe-Gly dipeptide to generate the derivatives PzCH2-Phe-Gly (H 3L2, 7) and PyCH2-Phe-Gly (H3L 3, 8) respectively, which contain ATCUN-like metal ion binding sites. The crystal structures of 1 and the copper(II) complexes Cu(L1) 2(H2O)2 (2) and [nBu4N][Cu(L 2)] (9) are described. Complex 2 has a tetragonally-elongated, Jahn-Teller distorted octahedral geometry and complex 9 is square-planar, The structural similarity of the copper(II) complexes of 7 and 8 is demonstrated by their almost identical electronic absorption and EPR spectra. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Use of low-volatility pyrazole derivatives having hydrophilic groups as nitrification inhibitors

The present invention provides pyrazole compounds which are useful as nitrification inhibitors.

Fungicidal compositions

N-Acylated N-phenyl-aminotetrahydro-2-furanones of the formula I are valuable fungicidal active substances. They can be used as fungicidal compositions, particularly for combatting phytopathogenic fungi, e.g. against downy mildew on potatoes, tomatoes, gr

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.