Technology Process of (RS)-3-(1-phenyl-1-ethylsulfonyl)-N-benzyl-N-methyl-6-fluoro-1H-indazole-1-acetamide
There total 7 articles about (RS)-3-(1-phenyl-1-ethylsulfonyl)-N-benzyl-N-methyl-6-fluoro-1H-indazole-1-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-benzyl-N-methyl-3-(benzylsulfonyl)-6-fluoro-1H-indazole-1-acetamide;
With
sodium hydride;
In
N,N-dimethyl-formamide; oil;
at 0 - 20 ℃;
for 2h;
methyl iodide;
In
N,N-dimethyl-formamide; oil;
for 24h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide
2.1: potassium carbonate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 18 h / 90 °C / Sealed tube
3.1: sodium hydrogencarbonate; Oxone / water; acetone / 2 h / 0 - 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C
5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
6.2: 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide; oil / 2 h / 0 - 20 °C
7.2: 24 h
With
Oxone; water; iodine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; ethylene glycol; 1,1'-carbonyldiimidazole; potassium hydroxide; sodium hydroxide;
copper(l) iodide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 18 h / 90 °C / Sealed tube
2.1: sodium hydrogencarbonate; Oxone / water; acetone / 2 h / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
5.2: 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; oil / 2 h / 0 - 20 °C
6.2: 24 h
With
Oxone; water; sodium hydride; sodium hydrogencarbonate; potassium carbonate; ethylene glycol; 1,1'-carbonyldiimidazole; sodium hydroxide;
copper(l) iodide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; oil;
