BENZYL-2,3,4,5,6-D5 BROMIDE

Base Information

• Chemical Name: BENZYL-2,3,4,5,6-D5 BROMIDE
• CAS No.: 71258-22-5
• Molecular Formula: C7H2 Br D5
• Molecular Weight: 175.997
• Mol file: 71258-22-5.mol

Synonyms:Benzene-d5,(bromomethyl)- (9CI)

Chemical Property of BENZYL-2,3,4,5,6-D5 BROMIDE

Chemical Property:

• PSA: 0.00000
• LogP: 2.58150

Purity/Quality:

98.5% ^*data from raw suppliers

Benzyl-d5 Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: BENZYL-2,3,4,5,6-D5 BROMIDE is a compound used in organic synthesis for the introduction of the benzyl protecting group for alcohols and carboxylic acids.

Technology Process of BENZYL-2,3,4,5,6-D5 BROMIDE

There total 7 articles about BENZYL-2,3,4,5,6-D5 BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

<2,3,4,5,6-D5>-benzyl alcohol (68661-10-9) → benzyl bromide (71258-22-5)

Guidance literature:

With bromine; triphenylphosphine; In acetonitrile; at 55 ℃;

DOI:10.1002/jms.1089

Reference yield:

2,3,4,5,6-pentadeuteriotoluene (1603-99-2) → benzyl bromide (71258-22-5)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 20h; Heating;

Reference yield:

1,3,5-Trioxan (110-88-3) + benzene-d6 (1076-43-3) → benzyl bromide (71258-22-5)

Guidance literature:

With hydrogen bromide; cetyltrimethylammonium bromide; acetic acid; for 24h; Heating;

DOI:10.1021/ja00056a013

upstream raw materials:

1,3,5-Trioxan

benzene-d6

formaldehyd

2,3,4,5,6-pentadeuteriotoluene

Refernces

• 1、 Bialecki, Jason,Ruzicka, Josef,Attygalle, Athula B.. "An unprecedented rearrangement in collision-induced mass spectrometric fragmentation of protonated benzylamines". . p. 1195 - 1204. Retrieved 2007/10/03.
• 2、 Hartz, Nikolai,Surya Prakash,Olah, George A.. "Mechanism of the reaction of methylene with benzene: A study of kinetic hydrogen isotope effects and theoretical calculations". . p. 901 - 905. Retrieved 2007/10/02.