Technology Process of (S)‐1‐(o‐tolyl)prop‐2‐en‐1‐ol
There total 2 articles about (S)‐1‐(o‐tolyl)prop‐2‐en‐1‐ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate; C36H40Cl2N2P2Ru;
In
dichloromethane; toluene;
at 23 ℃;
for 1h;
enantioselective reaction;
Inert atmosphere;
Glovebox;
DOI:10.3390/molecules26247475
- Guidance literature:
-
vinyl magnesium bromide;
With
Bis<2-(N,N-dimethylamino)aethyl>aether;
In
tert-butyl methyl ether;
at 0 ℃;
for 1.5h;
Inert atmosphere;
2-methylphenyl aldehyde;
With
butyl magnesium bromide; 3,3’-dimethyl-[1,1’-binaphthalene]-2,2’-diol;
In
tert-butyl methyl ether;
at -20 - 0 ℃;
for 5.5h;
Overall yield = 46 %; enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chir.23038
- Guidance literature:
-
(S)‐1‐(o‐tolyl)prop‐2‐en‐1‐ol;
With
(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']diphenyl-4-en)-dibenzo[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; aminosulfonic acid; lithium iodide;
In
N,N-dimethyl-formamide; toluene;
at 23 ℃;
for 18h;
Molecular sieve;
Inert atmosphere;
benzoyl chloride;
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
at 0 - 23 ℃;
stereospecific reaction;
Inert atmosphere;
DOI:10.1021/ja105271z
