ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

Base Information

Chemical Name:ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate
CAS No.:1413281-76-1
Molecular Formula:C₁₇H₁₅ClF₃NO₄
Molecular Weight:389.759
Hs Code.:

Synonyms:ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

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Chemical Property of ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

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Technology Process of ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

There total 5 articles about ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

: 1413281-75-0
ethyl 2,4-dichloro-6-(trifluoromethyl)nicotinate

: 105-13-5
4-Methoxybenzyl alcohol

: 1413281-76-1
ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

Reference yield:

: 947144-28-7
ethyl 2,4-dihydroxy-6-(trifluoromethyl)nicotinate

: 1413281-76-1
ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 90 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.094

Reference yield:

: 947144-30-1
3-(2-ethoxycarbonylacetylamino)-4,4,4-trifluorobut-2-enoic acid ethyl ester

: 1413281-76-1
ethyl 2-chloro-4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / ethanol / 2 h / 20 - 70 °C / Inert atmosphere

2: trichlorophosphate / N,N-dimethyl-formamide / 48 h / 0 - 110 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 °C

With potassium tert-butylate; sodium hydride; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;