5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

Base Information

Chemical Name:5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a
CAS No.:261911-91-5
Molecular Formula:C₆₃H₉₆O₁₆Si
Molecular Weight:1137.53
Hs Code.:

5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B<sub>1a</sub>

Synonyms:5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

Suppliers and Price of 5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

Chemical Property:

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Technology Process of 5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

There total 2 articles about 5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 81924-41-6
5-O-(tert-butyldimethylsilyl)avermectin B_1a

: 102331-29-3
2-phenoxyethoxymethyl chloride

: 261911-91-5
5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h;
DOI:10.1016/S0968-0896(99)00259-X

Reference yield:

: 122-99-6,56257-90-0,9004-78-8
2-Phenoxyethanol

: 261911-91-5
5-O-(tert-butyldimethylsilyl)-4-O-(2-phenoxyethoxymethyl)avermectin B_1a

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / toluene

2: 57 percent / diisopropylethylamine / CH₂Cl₂ / 24 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; 1: chloromethylation / 2: Etherification;
DOI:10.1016/S0968-0896(99)00259-X