2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline

Base Information

• Chemical Name: 2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline
• CAS No.: 853021-32-6
• Molecular Formula: C₂₄H₂₄N₂O₃
• Molecular Weight: 388.466
• Mol file: 853021-32-6.mol

Synonyms:2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline

Chemical Property of 2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline

There total 1 articles about 2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline (53416-46-9) + 4-(2'-pyridyl)benzaldehyde (127406-56-8) → 2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline (853021-32-6)

Guidance literature:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 4h;

4-(2'-pyridyl)benzaldehyde; In diethyl ether; hexane; at 0 - 20 ℃;

DOI:10.1021/jo047841z

Reference yield: 62.0%

2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline (853021-32-6) → 3-[4'-(2''-pyridyl)phenyl]-5-methoxyphthalide (853021-33-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 2.5h; Heating;

DOI:10.1021/jo047841z

Reference yield:

2-[2'-(4''-(2'''-pyridyl)phenyl)hydroxymethyl-4'-methoxyphenyl]-4,4-dimethyl-2-oxazoline (853021-32-6) → 4-methoxy-2-[(4'-(2''-pyridyl)phenyl)methyl]benzoic acid (853021-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / p-toluenesulfonic acid / toluene / 2.5 h / Heating

2: 75 percent / zinc; acetic acid / 24 h / Heating

With toluene-4-sulfonic acid; acetic acid; zinc; In toluene;

DOI:10.1021/jo047841z

upstream raw materials:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4-(2'-pyridyl)benzaldehyde

Downstream raw materials:

3-[4'-(2''-pyridyl)phenyl]-5-methoxyphthalide

4-methoxy-2-[(4'-(2''-pyridyl)phenyl)methyl]benzoic acid