Rivaroxaban iMpurity

Base Information

• Chemical Name: Rivaroxaban iMpurity
• CAS No.: 1616563-62-2
• Molecular Formula: C₁₅H₁₇N₃O₅
• Molecular Weight: 319.317
• Mol file: 1616563-62-2.mol

Synonyms:N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide

Chemical Property of Rivaroxaban iMpurity

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Rivaroxaban iMpurity

There total 5 articles about Rivaroxaban iMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one (446292-10-0,1411775-06-8) + formic acid (64-18-6) → N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide (1616563-62-2)

Guidance literature:

In toluene; at 110 - 120 ℃; Solvent;

Reference yield: 80.0%

formic acid (64-18-6) + 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride (898543-06-1) → N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide (1616563-62-2)

Guidance literature:

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride; With ammonia; In dichloromethane; for 0.25h;

formic acid; In water; toluene; at 110 - 120 ℃;

Reference yield:

2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione (446292-07-5) → N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide (1616563-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 8 h / 25 - 30 °C

2.1: methylamine / water; methanol / 5 h / 25 - 65 °C

2.2: 0.5 h / 25 - 30 °C / pH 1 - 2

3.1: ammonia / dichloromethane / 0.25 h

3.2: 110 - 120 °C

With ammonia; methylamine; In methanol; dichloromethane; water;

upstream raw materials:

formic acid

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

Rivaroxaban

Refernces