N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

Base Information

Chemical Name:N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide
CAS No.:1383129-45-0
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

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Technology Process of N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

There total 2 articles about N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 4843-44-1
(2-thienyl)propiolic acid

: 625842-54-8
N-(2,2-diethoxyethyl)-4-methoxyaniline

: 1383129-45-0
N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c2cc32783j

Reference yield:

: 696-62-8
para-iodoanisole

: 1383129-45-0
N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 40 h / 80 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; copper(l) iodide; potassium carbonate; dicyclohexyl-carbodiimide; L-proline; In dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2cc32783j