4843-44-1

Basic information

• Product Name: 2-Propynoic acid, 3-(2-thienyl)-
• CAS NO: 4843-44-1
• Molecular Formula: C7H4O2S
• Molecular Weight: 152.174
• Mol File: 4843-44-1.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 2-Propynoic acid, 3-(2-thienyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynoic acid, 3-(2-thienyl)-(4843-44-1)
• EPA Substance Registry System: 2-Propynoic acid, 3-(2-thienyl)-(4843-44-1)

Safety Data

• Hazardous Substances Data: 4843-44-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 4467, 1972 DOI: 10.1021/jo00799a040

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 124-38-9 carbon dioxide 
• 77295-66-0 2-(2,2-dibromovinyl)thiophene 
• 4298-52-6 2-ethynyl-thiophene 
• 40231-03-6 2-(trimethylsilylethynyl)thiophene 
• 1003-09-4 2-bromothiophene 
• 471-25-0 Propiolic acid 
• 3437-95-4 2-Iodothiophene 
• 1124-65-8 3-(2-thienyl)-2-propenoic acid 
• 91585-46-5 2-Phenylselanyl-1-thiophen-2-yl-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 1777-61-3 1-(thiophen-2-yl)-2-(triphenylphosphoranylidene)ethan-1-on 
• 6836-79-9 2-bromo-3-(thiophen-2-yl)acrylic acid 
• 6824-26-6 methyl 3-(2-thiophenyl)-2-propynoate 
• 91585-37-4 2-((phenylselanyl)ethynyl)thiophene 

Downstream Products

• 109034-47-1 2-(2-thienyl)-6-phenyltellura-4H-pyran-4-one 
• 131292-11-0 ethyl 5-(2-thienyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate 
• 1383129-45-0 N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(thiophen-2-yl)propiolamide 
• 55968-16-6 2-(2-thienyl)indole 
• 29784-20-1 1-phenyl-3-(thiophen-2-yl)prop-2-yn-1-one 
• 6297-63-8 2-(2-thienyl)-4H-1-benzopyran-4-one 
• 35095-36-4 6-methoxy-2-(thiophen-2-yl)-4H-chromen-4-one 
• 7209-74-7 6-chloro-2-(thiophen-2-yl)-4H-chromen-4-one 

Relevant articles and documents

Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Napthyridinone Derivatives

1,6-Enynes have recently stimulated enormous attention toward paving the way to unique cascade cyclizations offering complex cyclic motifs from linear substrates. We describe herein a general approach to napthyridinones via the Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. This protocol represents a rare carbo-aminative annulative cyclization via the 6-endo-trig mode, subduing the well-documented exo-trig/dig cyclizations. The regioselective aryl palladation of alkyne followed by Heck-type intramolecular coupling before isomerization were key in realizing this cascade.

Organocatalytic Strategy for the Fixation of CO2via Carboxylation of Terminal Alkynes

An organocatalytic strategy for the direct carboxylation of terminal alkynes with CO2 has been developed. The combined use of a bifunctional organocatalyst and Cs2CO3 resulted in a robust catalytic system for the preparation of a range of propiolic acid derivatives in high yields with broad substrate scope using CO2 at atmospheric pressure under mild temperatures (60 °C). This work has demonstrated that this organocatalytic method offers a competitive alternative to metal catalysis for the carboxylation of terminal alkynes and CO2. In addition, this protocol was suitable for the three-component carboxylation of terminal alkynes, alkyl halides, and CO2.

Access to Triazolopiperidine Derivatives via Copper(I)-Catalyzed [3+2] Cycloaddition/Alkenyl C?N Coupling Tandem Reactions

A copper-catalyzed [3+2] cylcoaddition/ alkenyl C?N coupling tandem reaction was demonstrated. It provided a method for the formation of triazolopiperidine skeletons. (Figure presented.).