(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

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Chemical Name:(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one
CAS No.:873326-08-0
Molecular Formula:C₃₄H₃₆N₂O₆
Molecular Weight:568.67
Hs Code.:

Synonyms:(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

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Chemical Property of (4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

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Technology Process of (4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

There total 1 articles about (4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 626-15-3
1,3-bis-(bromomethyl)benzene

: 873326-08-0
(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-3-propionyl-2-oxazolidinone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

1,3-bis-(bromomethyl)benzene; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 24h;
DOI:10.1002/chem.200500319

Reference yield: 90.0%

: 873326-08-0
(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

: 873326-09-1
(2S)-3-{3-[(2S)-2-carboxypropyl]phenyl}-2-methylpropanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-08-0
(4R)-4-benzyl-3-[(2S)-3-(3-{(2S)-3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3-oxopropyl}phenyl)-2-methylpropanoyl]-1,3-oxazolidin-2-one

: 873326-05-7
(2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 0 °C

2.1: 71 percent / DCC; DMAP / CH₂Cl₂ / 6 h / 23 °C

3.1: 64 percent / pig liver esterase; aq. NaOH; NaCl / methanol; aq. phosphate buffer / 12 h / 23 °C / pH 7 - 7.5

4.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

4.2: toluene / 3.5 h / Heating

5.1: 0.73 g / toluene / 20 h / Heating

6.1: 85 percent / aq. NaOH / tetrahydrofuran / 14 h / 23 °C

With dmap; lithium hydroxide; sodium hydroxide; pig liver esterase; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; dicyclohexyl-carbodiimide; sodium chloride; In tetrahydrofuran; methanol; phosphate buffer; dichloromethane; toluene; 4.2: Curtius rearrangement;
DOI:10.1002/chem.200500319