methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

Base Information

Chemical Name:methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate
CAS No.:873326-12-6
Molecular Formula:C₁₉H₂₉NO₄
Molecular Weight:335.444
Hs Code.:

Synonyms:methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

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Chemical Property of methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

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Technology Process of methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

There total 6 articles about methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873326-11-5
(2S)-3-{3-[(2S)-3-methoxy-2-methyl-3-oxopropyl]phenyl}-2-methylpropanoic acid

: 873326-12-6
methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

1.2: toluene / 3.5 h / Heating

2.1: 0.73 g / toluene / 20 h / Heating

With diphenyl phosphoryl azide; triethylamine; In toluene; 1.2: Curtius rearrangement;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-09-1
(2S)-3-{3-[(2S)-2-carboxypropyl]phenyl}-2-methylpropanoic acid

: 873326-12-6
methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 71 percent / DCC; DMAP / CH₂Cl₂ / 6 h / 23 °C

2.1: 64 percent / pig liver esterase; aq. NaOH; NaCl / methanol; aq. phosphate buffer / 12 h / 23 °C / pH 7 - 7.5

3.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

3.2: toluene / 3.5 h / Heating

4.1: 0.73 g / toluene / 20 h / Heating

With dmap; sodium hydroxide; pig liver esterase; diphenyl phosphoryl azide; triethylamine; dicyclohexyl-carbodiimide; sodium chloride; In methanol; phosphate buffer; dichloromethane; toluene; 3.2: Curtius rearrangement;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-10-4
methyl (2S)-3-{3-[(2S)-3-methoxy-2-methyl-3-oxopropyl]phenyl}-2-methylpropanoate

: 873326-12-6
methyl (2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / pig liver esterase; aq. NaOH; NaCl / methanol; aq. phosphate buffer / 12 h / 23 °C / pH 7 - 7.5

2.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

2.2: toluene / 3.5 h / Heating

3.1: 0.73 g / toluene / 20 h / Heating

With sodium hydroxide; pig liver esterase; diphenyl phosphoryl azide; triethylamine; sodium chloride; In methanol; phosphate buffer; toluene; 2.2: Curtius rearrangement;
DOI:10.1002/chem.200500319