4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

Base Information

Chemical Name:4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid
CAS No.:1373319-33-5
Molecular Formula:C₂₉H₃₄N₄O₇
Molecular Weight:550.612
Hs Code.:

Synonyms:4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

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Chemical Property of 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

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Technology Process of 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

There total 13 articles about 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1373319-45-9
methyl 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoate

: 1373319-33-5
4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2ob07125h

Reference yield:

: 159783-41-2
methyl 3-isopropyloxy-4-nitrobenzoate

: 1373319-33-5
4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

2: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

3: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

4: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; ethyl acetate;
DOI:10.1039/c2ob07125h

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1373319-33-5
4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 12 h / 0 °C / Reflux; Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere

2.2: 16 h / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

4.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

7.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

8.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With thionyl chloride; tin(II) chloride dihdyrate; palladium 10% on activated carbon; water; hydrogen; triphenylphosphine; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; ethyl acetate;
DOI:10.1039/c2ob07125h