7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one
• CAS No.: 281225-36-3
• Molecular Formula: C₂₆H₁₇ClFN₃O₂S
• Molecular Weight: 489.957

Synonyms:7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

Chemical Property of 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

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Technology Process of 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

There total 3 articles about 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Methoxyphenyl isothiocyanate (2284-20-0) + 2-amino-6-(4-chloro-phenyl)-4-(4-fluoro-phenyl)-nicotinamide (190319-70-1) → 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one (281225-36-3)

Guidance literature:

In diphenylether; for 9h; Heating;

DOI:10.1080/10426509808033729

Reference yield:

1-(4-chlorophenyl)-3-(4-fluorophenyl)prop-2-en-1-one (126443-14-9,98991-31-2) → 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one (281225-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₃COONH₄ / ethanol / 22 h / Heating

2: ethanolic KOH / 22 h / Heating

3: 70 percent / diphenyl ether / 9 h / Heating

With potassium hydroxide; ammonium acetate; In diphenylether; ethanol; 1: Condensation / 2: Hydrolysis / 3: Cyclization;

DOI:10.1080/10426509808033729

Reference yield:

2-amino-3-cyano-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyridine (160031-97-0) → 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one (281225-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanolic KOH / 22 h / Heating

2: 70 percent / diphenyl ether / 9 h / Heating

With potassium hydroxide; In diphenylether; 1: Hydrolysis / 2: Cyclization;

DOI:10.1080/10426509808033729

upstream raw materials:

4-Methoxyphenyl isothiocyanate

2-amino-6-(4-chloro-phenyl)-4-(4-fluoro-phenyl)-nicotinamide

1-(4-chlorophenyl)-3-(4-fluorophenyl)prop-2-en-1-one

2-amino-3-cyano-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyridine

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