2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

Base Information

Chemical Name:2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester
CAS No.:1327310-65-5
Molecular Formula:C₁₅H₁₆ClFO₄
Molecular Weight:314.741
Hs Code.:

Synonyms:2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

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Chemical Property of 2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

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Technology Process of 2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

There total 1 articles about 2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1327310-91-7
C₉H₇Cl₂FO

: 599-04-2
(R)-Pantolacton

: 1327310-65-5
2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tet.2011.06.055

Reference yield:

: 1327310-65-5
2-chloro-2-(4-fluoro-2-methylphenyl)acetic acid (R)-pantolactone ester

: 140-28-3,87170-83-0
N,N'-Dibenzylethylenediamine

: 1327310-75-7
1,4-dibenzyl-(S)-3-(4-fluoro-2-methylphenyl)-2-piperazinone

: 1,4-dibenzyl-(R)-3-(4-fluoro-2-methylphenyl)-2-piperazinone

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; optical yield given as %ee; stereoselective reaction;
DOI:10.1016/j.tet.2011.06.055