C₁₀H₉N₃O₂

Base Information

• Chemical Name: C₁₀H₉N₃O₂
• CAS No.: 1206797-34-3
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Mol file: 1206797-34-3.mol

Synonyms:C₁₀H₉N₃O₂

Chemical Property of C₁₀H₉N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₉N₃O₂

There total 2 articles about C₁₀H₉N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl β-(o-aminophenyl)acrylate (88939-75-7,1664-62-6) → C10H9N3O2 (1206797-34-3)

Guidance literature:

methyl β-(o-aminophenyl)acrylate; With sodium nitrite; In water; acetic acid; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;

With sodium azide; In water; acetic acid; at 0 - 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201510045

Reference yield:

2-bromoaniline (615-36-1) → C10H9N3O2 (1206797-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / 20 h / 125 °C / Inert atmosphere; Schlenk technique

2.1: sodium nitrite / water; acetic acid / 1 h / 0 °C / Inert atmosphere; Schlenk technique

2.2: 1 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium nitrite; In water; acetic acid; 1.1: |Heck Reaction;

DOI:10.1002/anie.201510045

Reference yield: 89.0%

C10H9N3O2 (1206797-34-3) → indole-2-carboxylic acid methyl ester (1202-04-6)

Guidance literature:

With 5,10,15,20-tetrakis(pentafluorophenyl)-21H,23H-porphyrin iron(III) chloride; In 1,2-dichloro-ethane; for 24h; Molecular sieve; Reflux; Inert atmosphere;

DOI:10.1039/c0cc01825b

upstream raw materials:

methyl β-(o-aminophenyl)acrylate

2-bromoaniline

Downstream raw materials:

indole-2-carboxylic acid methyl ester