C₁₄H₂₃NO

Base Information

• Chemical Name: C₁₄H₂₃NO
• CAS No.: 1380414-57-2
• Molecular Formula: C₁₄H₂₃NO
• Molecular Weight: 221.343
• Mol file: 1380414-57-2.mol

Synonyms:C₁₄H₂₃NO

Chemical Property of C₁₄H₂₃NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₄H₂₃NO

There total 2 articles about C₁₄H₂₃NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(+/-)-7-(phenylsulfinyl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one + n-hexylmagnesium bromide (3761-92-0) → n-hexyl phenyl sulfoxide (117939-92-1,131433-42-6,131433-44-8,13606-31-0) + 2,3,8,8a-tetrahydroindolizin-5(1H)-one (1127345-23-6) + C14H23NO (1380414-57-2)

Guidance literature:

(+/-)-7-(phenylsulfinyl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one; n-hexylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 6h;

With acetic acid; In tetrahydrofuran; Cooling with ice;

With methanol; sodium tetrahydroborate; In tetrahydrofuran; for 0.5h;

DOI:10.1016/j.tet.2012.04.054

Reference yield:

7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone (871950-84-4) → n-hexyl phenyl sulfoxide (117939-92-1,131433-42-6,131433-44-8,13606-31-0) + 2,3,8,8a-tetrahydroindolizin-5(1H)-one (1127345-23-6) + C14H23NO (1380414-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 0 - 20 °C

2.1: tetrahydrofuran / 6 h / 20 °C

2.2: Cooling with ice

2.3: 0.5 h

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 2.1: Grignard reaction;

DOI:10.1016/j.tet.2012.04.054

upstream raw materials:

7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone

n-hexylmagnesium bromide