4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole

Base Information

• Chemical Name: 4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole
• CAS No.: 616895-00-2
• Molecular Formula: C₁₂H₁₃BrClNO₂S
• Molecular Weight: 350.664
• Mol file: 616895-00-2.mol

Synonyms:4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole

Chemical Property of 4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole

There total 1 articles about 4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-chlorophenyl)-3,3,4-trimethyl-2,3-dihydro-isothiazole-1,1-dioxide (416855-47-5) → 4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole (616895-00-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 4h; Heating / reflux;

Reference yield: 93.0%

4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole (616895-00-2) + 2-fluoroethylamine hydrochloride (460-08-2) → N-(5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl)methyl-N-(2-fluoroethyl)amine (616894-99-6)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 16h;

Reference yield: 43.0%

4-bromomethyl-5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-isothiazole (616895-00-2) + N-methoxylamine hydrochloride (593-56-6) → N-(5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl) methyl-O-methyl-hydroxylamine (616895-01-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

upstream raw materials:

5-(4-chlorophenyl)-3,3,4-trimethyl-2,3-dihydro-isothiazole-1,1-dioxide

Downstream raw materials:

N-(5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl) methyl-O-methyl-hydroxylamine

[5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-ylmethyl]ethylamine

N-(5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl)methyl-N-(2-fluoroethyl)amine