phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

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Chemical Name:phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate
CAS No.:214899-52-2
Molecular Formula:C₂₂H₂₁N₃O₅
Molecular Weight:407.426
Hs Code.:

Synonyms:phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

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Chemical Property of phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

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Technology Process of phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

There total 11 articles about phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86139-03-9
phenylmethyl 2-ethynyl-1(2H)-pyridinecarboxylate

: 52606-03-8
2,6-dimethoxypyrimidine-4-carboxaldehyde

: 214899-52-2
phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

Guidance literature:: With ethylmagnesium bromide;
DOI:10.1016/S0040-4039(98)01470-1

Reference yield: 62.0%

: C₁₅H₁₂BrMgNO₂

: 52606-03-8
2,6-dimethoxypyrimidine-4-carboxaldehyde

: 214899-52-2
phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

Guidance literature:: With ethylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/ja000647j

Reference yield:

: 282100-54-3
4-hydroxymethyl-2,6-dimethoxypyrimidine

: 214899-52-2
phenylmethyl 2-[3-hydroxy-3-[4,6-dimethoxy-2-pyrimidinyl]-1-propynyl]-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

2: 62 percent / EtMgBr / tetrahydrofuran / 2 h / 0 °C

With ethylmagnesium bromide; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 1: Oxidation / 2: Addition;
DOI:10.1021/ja000647j