N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Base Information

Chemical Name:N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine
CAS No.:857900-01-7
Molecular Formula:C₃₇H₅₄N₂O₂
Molecular Weight:558.848
Hs Code.:

Synonyms:N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

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Chemical Property of N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

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Technology Process of N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

There total 3 articles about N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-methanesulfonate1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 134834-34-7
12-iodododecanol benzyl ether

: 857900-01-7
N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Guidance literature:: 12-iodododecanol benzyl ether; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.666667h;

With magnesium bromide ethyl etherate; In diethyl ether; pentane; at 20 ℃; for 0.0833333h;

Trifluoro-methanesulfonate1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;; In diethyl ether; dichloromethane; pentane; at -78 - -70 ℃; for 12h;
DOI:10.1021/ol051022z

Reference yield:

: 110-86-1
pyridine

: 857900-01-7
N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

2.1: t-BuLi / diethyl ether; pentane / 0.67 h / -78 °C

2.2: magnesium bromide diethyl etherate / diethyl ether; pentane / 0.08 h / 20 °C

2.3: 559 mg / CH₂Cl₂; diethyl ether; pentane / 12 h / -78 - -70 °C

With tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol051022z

Reference yield:

: 87768-46-5
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide

: 857900-01-7
N-[(1E)-[(2R)-2-[12-(benzyloxy)dodecyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

2.1: t-BuLi / diethyl ether; pentane / 0.67 h / -78 °C

2.2: magnesium bromide diethyl etherate / diethyl ether; pentane / 0.08 h / 20 °C

2.3: 559 mg / CH₂Cl₂; diethyl ether; pentane / 12 h / -78 - -70 °C

With tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol051022z