Technology Process of 2-[1-(3-methoxy-phenyl)-propyl]-malononitrile
There total 2 articles about 2-[1-(3-methoxy-phenyl)-propyl]-malononitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(3-methoxybenzylidene)malononitrile; ethylmagnesium bromide;
In
tetrahydrofuran;
at -15 - 25 ℃;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; water;
at 0 - 5 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 50 - 60 °C
2.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere
2.2: 0 - 5 °C
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C
1.2: 1 h / 25 °C
2.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 10 h / Reflux
2.2: 20 °C
3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C
3.2: pH 1
4.1: di-isopropyl ether / 6 h / 20 - 75 °C
5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C
6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C
7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C
8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere
8.2: 0.5 h / 0 - 5 °C
With
hydrogenchloride; thionyl chloride; dimethylsulfide borane complex; tri-n-butyl-tin hydride; sodium carbonate; potassium carbonate; sodium hydroxide;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; tert-butyl methyl ether; di-isopropyl ether; water; ethylene glycol; dimethyl sulfoxide; toluene;
