N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide
CAS No.:1437316-68-1
Molecular Formula:C₂₂H₁₄F₃N₇O₂S
Molecular Weight:497.46
Hs Code.:

Synonyms:N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

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Technology Process of N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

There total 8 articles about N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: C₂₇H₂₂F₃N₇O₃S

: 1437316-68-1
N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2016.03.055

Reference yield:

: 946826-47-7
N-(3-amino-2,6-difluorophenyl)acetamide

: 1437316-68-1
N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 1.5 h / 20 °C

2: hydrogenchloride / ethanol; water / 14 h / 90 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 20 °C

4: hydrogenchloride / water; tetrahydrofuran / 16 h / 20 °C

With pyridine; hydrogenchloride; dmap; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2016.03.055

Reference yield:

: C₁₄H₁₁F₃N₂O₃S

: 1437316-68-1
N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 14 h / 90 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 20 °C

3: hydrogenchloride / water; tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2016.03.055